Embedded Files
(2024)（学会発表）The relationship between cumulative exposure dose of anticancer drugs and contractile force inhibition in an in vitro toxicity test using human induced pluripotent stem cell derived cardiomyocytes, Yuto Hinata, Yuki Kagawa, Hirotsugu Kubo, Tomohiko Taniguchi, Kohei Sawada, Takashi Yoshinaga.第15回日本安全性薬理研究会（2024年2月22日(木)～23日(金)、大阪）
（学会発表）Actin filament disruption for in vitro cardiotoxicity evaluation of anti-cancer drugs, Toshiki SAOTOME, Yuki Toyama, Yoshimi Yasuda, Naoki SHIMADA, Kohei SAWADA第15回日本安全性薬理研究会（2024年2月22日(木)～23日(金)、大阪）
(2023)（学会発表）ヒトiPS分化細胞のアクチンフィラメント崩壊に基づく抗がん剤毒性の評価、早乙女 俊樹，安田 好美，遠山 由貴，島田 直樹，澤田 光平第6回 医薬品毒性機序研究会（2023年12月5日(火)～6日(水)、筑波）
（学会発表）ヒトiPS細胞由来心筋細胞を用いたPM2.5の毒性評価システムの構築、遠山由貴、早乙女俊樹、島田直樹、澤田光平3 6回日本動物実驗代替法学会（2023年11月27日(月)～29日(水)、千葉）
（学会発表）Chronic cardiotoxicity evaluation of doxorubicin based on changes in contractile force of cell sheet tissues made from human induced pluripotent stem cell-derived cardiomyocytes, Yuto Hinata, Yuki Kagawa, Hirotsugu Kubo, Eriko Kato, Atsushi Baba, Daisuke Sasaki, Katsuhisa Matsuura, Tatsuya Shimizu , Kohei Sawada第50回日本毒性学会学術年会（The 50th Annual Meeting of the Japanese Society of Toxicology）（2023年6月19日（月）～6月21日（水）、横浜）
（学会発表）A new analysis tool “C-V loop” for evaluating the drug effects on contractile kinetics of cardiomyocytes第14回日本安全性薬理研究会学術年会（2023年2月17-18日、東京大学）
（学会発表）Disruption of actin cytoskeleton may underlie the contractile dysfunction with HDAC inhibitors in human iPS cell-derived cardiomyocytes第14回日本安全性薬理研究会学術年会（2023年2月17-18日、東京大学）
（学会発表）Characterization of Multi Aspects of Cardio Toxicity with Anti-Cancer Agents Using Human iPSC Derived Cardiomyocytes Cultured on Gelatin Fiber Network2022 Safety Pharmacology Society (SPS )Annual Meeting（September 11 - January 1, 2023 (On site & Web)、Montréal, Quebec, Canada）
（学会発表）Assessment of Drug-Induced Toxicity on Human iPS Cell-Derived Neuronal Cells In Vitro Gelatin Fiber Scaffold Model2022 Safety Pharmacology Society (SPS )Annual Meeting（September 11 - January 1, 2023 (On site & Web)、Montréal, Quebec, Canada）
(2022)Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytesJournal of Pharmacological and Toxicological Methods, Volume 118, November–December 2022
(2020)（研究支援等）再生医療等安全性確保法における原料及び細胞加工物の保管に関する管理基準の策定に資する研究（厚生労働科学研究費補助金行政政策研究分野厚生労働科学特別研究事業）
Inutsuka T., Okamoto M. Burnout syndrome – Prevention and measures to keep everyone working with satisfaction. Clinc res ther rev 1(1): 8–11 (2020)
(2019)（研究支援等）日本のアカデミアにおける医療系ベンチャーのシーズの網羅的探索と成長要因解析（平成３０年度厚生労働科学研究費補助金政策科学総合研究事業（政策科学推進研究事業））
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. Silver nanoparticles inhibits neural differentiation in human iPS Cells. Journal of Pharmacological and Toxicological Methods 99; 106595-106595 (2019).
Yamada Shigeru, Kanda Yasunari. Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers. Journal of Pharmacological Sciences 140; 337-344 (2019)
(2018)Takashi Inutsuka, Maya Okamoto, Yasuo Yoshimi, Risako Mori, Yuto Katsumata, Kenji Umeta. New Approach for Neuropharmacology Profile: In-Situ Real-Time Neuropharmacology Monitoring by Imaging Technique Using the Molecularly Imprinted Polymers (MIPs). Safety Pharmacology Society 2018 Annual Meeting. (PDF-7MB)
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. The Journal of Toxicological Sciences 43; 727-734 (2018)
Yamada Shigeru, Kubo Yusuke, Yamazaki Daiju, Sekino Yuko, Nomura Yoko, Yoshida Sachiko, Kanda Yasunari. Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells. Scientific Reports 8; 12155 (2018)
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. Silver nanoparticles inhibit neural induction in human induced pluripotent stem cells. Nanotoxicology 12; 836-846 (2018)
(2017)Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi, Hiroyuki Yamakawa, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Hidenori Tani, Li Wang, Li Qian, Makoto Inoue, Yoshinori Ide, Junko Kurokawa, Tsunehisa Yamamoto, Tomohisa Seki, Ryo Aeba, Hiroyuki Yamagishi, Keiichi Fukuda, Masaki Ieda. Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction. Cell Stem Cell. VOLUME 22, ISSUE 1, P91-103.E5, JANUARY 04, 2018.
犬塚, 井出. 「MEA Parser」の国際公開から得られたオープンサイエンスの考慮点. 研究・イノベーション学会年次学術大会講演要旨集 Volume 32, Octorber 2017, Pages 237-238.
Inutsuka T. The role of the “MEA Parser”: International release and perspectives. Curr Study Environ Med Sci 10. (PDF-577KB)
Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Brain & Development Volume 39, Issue 9, October 2017, Pages 774-782
Okamoto M et al. A COMPARATIVE STUDY OF DAILY MAXIMUM AND PERSONALLY EXPOSED TEMPERATURES DURING HOT SUMMER DAYS OVER THE PAST 7 YEARS IN KOBE, JAPAN --A study to improve “ Quality of Work (QoW) ” in working people. Work, Stress and Health 2017. (PDF - 475KB)
Inutsuka T et al. Role of common format data for studying new endpoints in microelectrode arrays (MEA) system. Curr Study Environ Med Sci 10.
Okamoto M et al. Organ-on-a-chip: Role and Perspective. Curr Study Environ Med Sci 10.
山田茂. アルツハイマー病患者の脳内で発見された大気中の人工ナノ粒子. ファルマシア Vol. 53 (2017) No. 3 p. 266 （2017年3月1日公開）
Yamada S, Kubo Y, Yamazaki D, Sekino Y, Kanda Y. Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human inducedpluripotent stem cells. Sci Rep. 2017 Jan 23;7:40925.
(2016)Kanda Y et al. Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system. Journal of Pharmacological and Toxicological Methods 81 (2016) 196–200.
Pamies D et al. Good Cell Culture Practice for stem cells and stem-cell-derived models. ALTEX Online first published October 5, 2016, version 4.
Ide Y et al. 0040 Cardiac Safety Assessment Methods for Human iPSC-Derived Cardiomyocytes: A Voltage Sensitive Dye Imaging with a High-speed CMOS Sensor and a Non-staining Imaging with Polarizers. The 2016 SPS/CSPT/JSPS Joint Meeting.
A. Alan Moghissi et al. A STUDENT GUIDE TO UNDERSTANDING REGULATORY SCIENCE.
(2014)A. Alan Moghissi et al. Regulatory science: An emerging new scientific discipline. Rinsho Hyoka; Clin Eval 41 (3) 2014: 597-608
Filipa A.C. Soares el al. International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper. Stem Cell Reports Volume 3, Issue 6, p931–939, 9 December 2014.
（学会発表）Actin filament disruption for in vitro cardiotoxicity evaluation of anti-cancer drugs, Toshiki SAOTOME, Yuki Toyama, Yoshimi Yasuda, Naoki SHIMADA, Kohei SAWADA第15回日本安全性薬理研究会（2024年2月22日(木)～23日(金)、大阪）
(2023)（学会発表）ヒトiPS分化細胞のアクチンフィラメント崩壊に基づく抗がん剤毒性の評価、早乙女 俊樹，安田 好美，遠山 由貴，島田 直樹，澤田 光平第6回 医薬品毒性機序研究会（2023年12月5日(火)～6日(水)、筑波）
（学会発表）ヒトiPS細胞由来心筋細胞を用いたPM2.5の毒性評価システムの構築、遠山由貴、早乙女俊樹、島田直樹、澤田光平3 6回日本動物実驗代替法学会（2023年11月27日(月)～29日(水)、千葉）
（学会発表）Chronic cardiotoxicity evaluation of doxorubicin based on changes in contractile force of cell sheet tissues made from human induced pluripotent stem cell-derived cardiomyocytes, Yuto Hinata, Yuki Kagawa, Hirotsugu Kubo, Eriko Kato, Atsushi Baba, Daisuke Sasaki, Katsuhisa Matsuura, Tatsuya Shimizu , Kohei Sawada第50回日本毒性学会学術年会（The 50th Annual Meeting of the Japanese Society of Toxicology）（2023年6月19日（月）～6月21日（水）、横浜）
（学会発表）A new analysis tool “C-V loop” for evaluating the drug effects on contractile kinetics of cardiomyocytes第14回日本安全性薬理研究会学術年会（2023年2月17-18日、東京大学）
（学会発表）Disruption of actin cytoskeleton may underlie the contractile dysfunction with HDAC inhibitors in human iPS cell-derived cardiomyocytes第14回日本安全性薬理研究会学術年会（2023年2月17-18日、東京大学）
（学会発表）Characterization of Multi Aspects of Cardio Toxicity with Anti-Cancer Agents Using Human iPSC Derived Cardiomyocytes Cultured on Gelatin Fiber Network2022 Safety Pharmacology Society (SPS )Annual Meeting（September 11 - January 1, 2023 (On site & Web)、Montréal, Quebec, Canada）
（学会発表）Assessment of Drug-Induced Toxicity on Human iPS Cell-Derived Neuronal Cells In Vitro Gelatin Fiber Scaffold Model2022 Safety Pharmacology Society (SPS )Annual Meeting（September 11 - January 1, 2023 (On site & Web)、Montréal, Quebec, Canada）
(2022)Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytesJournal of Pharmacological and Toxicological Methods, Volume 118, November–December 2022
(2020)（研究支援等）再生医療等安全性確保法における原料及び細胞加工物の保管に関する管理基準の策定に資する研究（厚生労働科学研究費補助金行政政策研究分野厚生労働科学特別研究事業）
Inutsuka T., Okamoto M. Burnout syndrome – Prevention and measures to keep everyone working with satisfaction. Clinc res ther rev 1(1): 8–11 (2020)
(2019)（研究支援等）日本のアカデミアにおける医療系ベンチャーのシーズの網羅的探索と成長要因解析（平成３０年度厚生労働科学研究費補助金政策科学総合研究事業（政策科学推進研究事業））
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. Silver nanoparticles inhibits neural differentiation in human iPS Cells. Journal of Pharmacological and Toxicological Methods 99; 106595-106595 (2019).
Yamada Shigeru, Kanda Yasunari. Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers. Journal of Pharmacological Sciences 140; 337-344 (2019)
(2018)Takashi Inutsuka, Maya Okamoto, Yasuo Yoshimi, Risako Mori, Yuto Katsumata, Kenji Umeta. New Approach for Neuropharmacology Profile: In-Situ Real-Time Neuropharmacology Monitoring by Imaging Technique Using the Molecularly Imprinted Polymers (MIPs). Safety Pharmacology Society 2018 Annual Meeting. (PDF-7MB)
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. The Journal of Toxicological Sciences 43; 727-734 (2018)
Yamada Shigeru, Kubo Yusuke, Yamazaki Daiju, Sekino Yuko, Nomura Yoko, Yoshida Sachiko, Kanda Yasunari. Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells. Scientific Reports 8; 12155 (2018)
Yamada Shigeru, Yamazaki Daiju, Kanda Yasunari. Silver nanoparticles inhibit neural induction in human induced pluripotent stem cells. Nanotoxicology 12; 836-846 (2018)
(2017)Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi, Hiroyuki Yamakawa, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Hidenori Tani, Li Wang, Li Qian, Makoto Inoue, Yoshinori Ide, Junko Kurokawa, Tsunehisa Yamamoto, Tomohisa Seki, Ryo Aeba, Hiroyuki Yamagishi, Keiichi Fukuda, Masaki Ieda. Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction. Cell Stem Cell. VOLUME 22, ISSUE 1, P91-103.E5, JANUARY 04, 2018.
犬塚, 井出. 「MEA Parser」の国際公開から得られたオープンサイエンスの考慮点. 研究・イノベーション学会年次学術大会講演要旨集 Volume 32, Octorber 2017, Pages 237-238.
Inutsuka T. The role of the “MEA Parser”: International release and perspectives. Curr Study Environ Med Sci 10. (PDF-577KB)
Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Brain & Development Volume 39, Issue 9, October 2017, Pages 774-782
Okamoto M et al. A COMPARATIVE STUDY OF DAILY MAXIMUM AND PERSONALLY EXPOSED TEMPERATURES DURING HOT SUMMER DAYS OVER THE PAST 7 YEARS IN KOBE, JAPAN --A study to improve “ Quality of Work (QoW) ” in working people. Work, Stress and Health 2017. (PDF - 475KB)
Inutsuka T et al. Role of common format data for studying new endpoints in microelectrode arrays (MEA) system. Curr Study Environ Med Sci 10.
Okamoto M et al. Organ-on-a-chip: Role and Perspective. Curr Study Environ Med Sci 10.
山田茂. アルツハイマー病患者の脳内で発見された大気中の人工ナノ粒子. ファルマシア Vol. 53 (2017) No. 3 p. 266 （2017年3月1日公開）
Yamada S, Kubo Y, Yamazaki D, Sekino Y, Kanda Y. Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human inducedpluripotent stem cells. Sci Rep. 2017 Jan 23;7:40925.
(2016)Kanda Y et al. Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system. Journal of Pharmacological and Toxicological Methods 81 (2016) 196–200.
Pamies D et al. Good Cell Culture Practice for stem cells and stem-cell-derived models. ALTEX Online first published October 5, 2016, version 4.
Ide Y et al. 0040 Cardiac Safety Assessment Methods for Human iPSC-Derived Cardiomyocytes: A Voltage Sensitive Dye Imaging with a High-speed CMOS Sensor and a Non-staining Imaging with Polarizers. The 2016 SPS/CSPT/JSPS Joint Meeting.
A. Alan Moghissi et al. A STUDENT GUIDE TO UNDERSTANDING REGULATORY SCIENCE.
(2014)A. Alan Moghissi et al. Regulatory science: An emerging new scientific discipline. Rinsho Hyoka; Clin Eval 41 (3) 2014: 597-608
Filipa A.C. Soares el al. International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper. Stem Cell Reports Volume 3, Issue 6, p931–939, 9 December 2014.
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