Pharmacological Evaluation Institute of Japan (PEIJ), General Incorporated Association

1. Mission

Pharmacological Evaluation Institute of Japan (PEIJ) is a non-profit pharmacology research institute in Japan. We support the activities for improvement in the reliability of the evaluation method of the toxicity and the safety used in the case of drug development, chemical safety and bio-security, as an "ADAPTER".

[Center for Pharmacological Science (CPS)]

MEA Parser: software to import raw data of MEA equipment and make the binary data of common format for international researcher

PEIJ is participating in the HESI Cardiac Safety Committee Myocyte Database Subteam; made and published "MEA Parser" which converts imported raw data of various MEA equipment (MED64, Maestro and MCS) into common binary data on the Windows, supported by AMED, so that it can be used internationally in the research for in vitro drug effects on human iPSc derived cardiomyocytes.

MEA Parser makes sense to store not only processed data but also raw data in the database for open science.

Every researchers using MED64/Maestro/MCS can access converted common binary data, and waveform analysis can be carried out with their own filter and wave analysis tools.

Researchers could develop new Endpoints in the international open science context.

MEA Parser website (MED64, Maestro, MCS(β))
 


We are also working with the Japan iPS Cardiac Safety Assessment (JiCSA), a consortium organized by Dr. Yuko Sekino / Dr. Yasunari Kanda, the National Institute of Health Sciences (NIHS), is engaged in a national project focused on cardiac safety assessment using in vitro drug effects on human iPSc derived cardiomyocytes, as a role of the developing the consortium's form. 
  • PEIJ harmonized CIPA Guiding Principles, which is a data sharing policy with CIPA, with CIPA on 2014/12/04 for JiCSA. 
  • PEIJ compiled the JiCSA general guidelines, which is the data sharing policy of JiCSA, with the consent of JiCSA members on 2015/05/22. 
  • PEIJ have provided JiCSA researchers with a validation work place in the PEIJ Lab. (2016/08-2017/08)
  • PEIJ is supporting the JiCSA activities such as JiCSA's homepage, groupware, video conference and JiCSA's paper translations. 
  • PEIJ is taking a role for developing a data platform, iPS Integrated Safety Assessment Tool (iSAT), and analyzation algorithms for the data mining, for the JiCSA activities.

[Center for Public Health (CPH)]
We are developing and using Organ-on-a-Chips for in vitro Assay System. 

PEIJ Microphysiological System Testing Center (MicSTeC)

We are developing and using Organ-on-a-Chips for in vitro Assay System at the PEIJ Microphysiological System Testing Center (MicSTeC) in the Center for Public Health (CPH).

2. Activity

[2017.08.30]
PEIJ exchanges information and opinions with Syril D. Pettit, Executive Director, ILSI Health and Environmental Sciences Institute (HESI)We are continuing to cooperate each other.

[2017.05.31]
PEIJ is an awardee of the Sciences Research Grant for Regenerative and Cell medicine industrialization project of the Kanagawa Prefecture. Under this project, we are working for JiCSA activity and developing Organ-on-a-Chips for in vitro Assay System.

[2017.04.03]
PEIJ provides the "MEA Parser"  (a software to import raw data of MEA equipment and make the binary data of common format, and display wave forms) to HESI Cardiac Safety Committee Myocyte Database Subteam.

[2017.04.01]
PEIJ is an awardee (FY2017), as a member of a research project, Japan iPS Cardiac Safety Assessment (JiCSA), of the Sciences Research Grant, the Research on Regulatory Science of Pharmaceuticals and Medical Devices of the Japan Agency for Medical Research and Development (AMED) in Japan.

[2016.10.27]
PEIJ attended the HESI Myocyte Database Subteam as a member and show our "iPS Integrated Safety Assessment Tool (iSAT)." Under this disucussion, PEIJ is preparing the open-source software "MEA Parser" to import raw data of MEA equipments and make the binary data of common format, and display wave forms.

[2016.10.14]
"Regenerative medicine & Cell therapy industrialization network of Kanagawa (RINK)" is established. PEIJ is one of the Executive secretary of the RINK.

[2016.09.28]
PEIJ received designation from Minister of Education, Culture, Sports, Science and Technology as the research institute where Grants-in-Aid for Scientific Research-KAKENHI- can be treated.

[2016.08.25]
The life Innovation Center (LIC), where PEIJ is in, opening ceremony is held on August 25, 2016.

[2016.08.15]
PEIJ decides and establishes two research centers for acceleration PEIJ's R&D activities.
- Center for Pharmacological Science (CPS)
- Center for Public Health (CPH) (Director Maya Okamoto, Ph.D.)

[2016.06.07]
PEIJ is an awardee of the Sciences Research Grant for Regenerative and Cell medicine industrialization project of the Kanagawa Prefecture. Under this project, we are working for JiCSA activity and developing Organ-on-a-Chips for in vitro Assay System.

[2016.04.01]
Our laboratory moves to the Life Innovation Center.

[2016.04.01]
PEIJ is an awardee (FY2016), as a member of a research project, Japan iPS Cardiac Safety Assessment (JiCSA), of the Sciences Research Grant, the Research on Regulatory Science of Pharmaceuticals and Medical Devices, for developing a data platform, iPS Integrated Safety Assessment Tool (iSAT), of the Japan Agency for Medical Research and Development (AMED) in Japan.

[2015.06.01-03]
PEIJ attended Good Cell Culture Practice for iPS workshop, 01-03 June, 2015, Baltimore, USA, as a member of JiCSA.

[2015.04.01]
PEIJ is an awardee (FY2015), as a member of a research project, Japan iPS Cardiac Safety Assessment (JiCSA), of the Sciences Research Grant, the Research on Regulatory Science of Pharmaceuticals and Medical Devices, for developing a data platform, iPS Integrated Safety Assessment Tool (iSAT), of the Japan Agency for Medical Research and Development (AMED) in Japan.

[2014.12.14-15]
PEIJ assists the symposium, Kanagawa Prefecture-NIH/NCATS Symposium -Translational Research Support and Human Resource Development between Japan and United States-, and sets up meetings with Dr. Petra Kaufmann (Director of Clinical Innovation, NCATS) and Dr. Danilo Tagle (Associate Director for Special Initiatives, NCATS).

[2014.9.23]
PEIJ assists the ISN satellite symposium, "Key molecules for neuronal maturation" -Application for validating the maturation of human iPSC-derived neurons-, 23 September, 2014, 13:00~17:20, Tokyo, Japan, and took a role in a general master of this symposium.

[2014.9]
PEIJ is an awardee (FY2014), as a member of a research project, (Japan iPS Cardiac Safety Assessment (JiCSA)), of the Sciences Research Grant of the Ministry of Health, Labour and Welfare in Japan.

[2014.5.12]
PEIJ was established.


3. Achievement

(2017)
Okamoto M et al. A COMPARATIVE STUDY OF DAILY MAXIMUM AND PERSONALLY EXPOSED TEMPERATURES DURING HOT SUMMER DAYS OVER THE PAST 7 YEARS IN KOBE, JAPAN --A study to improve “ Quality of Work (QoW) ” in working people. Work, Stress and Health 2017.

Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Brain & Development (in press)

Role of common format data for studying new endpoints in microelectrode arrays (MEA) system. Curr Study Environ Med Sci 10, in press (2017). 

Okamoto M et al. Organ-on-a-chip: Role and Perspective. Curr Study Environ Med Sci 10, in press (2017).

(2016)
Kanda Y et al. Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system. Journal of Pharmacological and Toxicological Methods 81 (2016) 196–200.

Pamies D et al. Good Cell Culture Practice for stem cells and stem-cell-derived models. ALTEX Online first published October 5, 2016, version 4.

Ide Y et al. 0040 Cardiac Safety Assessment Methods for Human iPSC-Derived Cardiomyocytes: A Voltage Sensitive Dye Imaging with a High-speed CMOS Sensor and a Non-staining Imaging with Polarizers. The 2016 SPS/CSPT/JSPS Joint Meeting.

A. Alan Moghissi et al. A STUDENT GUIDE TO UNDERSTANDING REGULATORY SCIENCE.

(2014)
A. Alan Moghissi et al. Regulatory science: An emerging new scientific discipline. Rinsho Hyoka; Clin Eval 41 (3) 2014: 597-608

4. About

Boards of Directors:
Shizuo Hoshiba (Representative Director)
Kazuyuki Imamura
Tomoaki Shirao
Norimasa Miyamoto

TEAM PEIJ:
Takashi Inutsuka (Research Managing Director)
Maya Okamoto, Ph.D. (Director, Center for Public Health)
Yoshinori Ide, Ph.D. (Senior Researcher, Center for Pharmacological Science)

PEIJ Laboratory:
3-25-22 Tonomachi, Life Innovation Center, Kawasaki-ku, Kawasaki-City, Kanagawa, Japan 210-0821

Tel: +81-44-272-7187
Fax: +81-50-3730-3851
email: peij*peij.or.jp (please replace * with @)