Pharmacological Evaluation Institute of Japan (PEIJ), General Incorporated Association

1. "make a future together"


Pharmacological Evaluation Institute of Japan (PEIJ) is a non-profit pharmacology research institute. We are working with the activities globally for improvement in the reliability of the evaluation method of toxicity / safety  and efficacy used in the case of drug development and chemical safety as an "ADAPTER"We are also working for STEAM education for all in the SDGs.

[Center for Public Health (CPH)]
We are developing and using Organ-on-a-Chips for in vitro Assay System. 

PEIJ Microphysiological System Testing Center (MicSTeC)

We are developing and using Organ-on-a-Chips for in vitro Assay System at the PEIJ Microphysiological System Testing Center (MicSTeC) in the Center for Public Health (CPH).

There are many opportunities in MicSTeC for researchers and companies; collaboration, prototype demonstration, getting information, analytic support etc. Everything you need for your organ-on-a-chip project.

And we understand the importance of the data stability from organ-on-a-chip, so we are collaborating internationally how we can solve this issue and what criteria we need with.

MicSTeC is also working for STEAM education for all in the SDGs using Organ-on-a-Chip.

"Bridging the gap between formal education and informal learning is clearly one of the future trends of our societies. In addition, it is important to combine empirical hands-on experiments with digital solutions. Traditional STEM-pedagogy becomes even more effective by adding the creative element of Art – to form STEAM." 
Dr. Hannu Salmi, Professor, CREATIONS-Project, University of Helsinki, Finland

[Center for Pharmacological Science (CPS)]

MEA Parser: software to import raw data of MEA equipment and make the binary data of common format for international researcher

PEIJ, member of the HESI Cardiac Safety Committee Myocyte Database Subteam, made and published "MEA Parser" which converts the imported raw data of various MEA equipment (MED64, Maestro and MCS) into common binary data on the Windows (stand-alone and do not need a connection to the network), supported by AMED, so that it can be used internationally in research for in vitro drug effects on human iPSc derived cardiomyocytes.

MEA Parser makes sense to store not only processed data but also raw data in the database for verification and open science.

Every researcher using MED64/Maestro/MCS can access converted common binary data, and waveform analysis can be carried out with their own filter and wave analysis tools.
Researchers can develop new endpoints in the international open science context.

MEA Parser website (MED64, Maestro, MCS(β))
 


We are also working with the Japan iPS Cardiac Safety Assessment (JiCSA), a consortium organized by Dr. Yasunari Kanda, the National Institute of Health Sciences (NIHS), is engaged in a national project focused on cardiac safety assessment using in vitro drug effects on human iPSc derived cardiomyocytes, as a role of the developing the consortium's form. 
  • PEIJ harmonized CIPA Guiding Principles, which is a data sharing policy with CIPA, with CIPA on 2014/12/04 for JiCSA. 
  • PEIJ compiled the JiCSA general guidelines, which is the data sharing policy of JiCSA, with the consent of JiCSA members on 2015/05/22. 
  • PEIJ have provided JiCSA researchers with a validation work place in the PEIJ Lab. (2016/08-2017/08)
  • PEIJ is supporting the JiCSA activities such as JiCSA's homepage, groupware, video conference and JiCSA's paper translations. 
  • PEIJ is taking a role for developing a data platform, iPS Integrated Safety Assessment Tool (iSAT), and analyzation algorithms for the data mining, for the JiCSA activities.



2. Activity

[2017.11.15-17]
Science Centre World Summit 2017 (SCWS2017)
PEIJ is working for STEAM education for all in the SDGs using Organ-on-a-Chip.

[2017.11.09] 
PEIJ attended the CiPA in-silico modelling workshop.

[2017.11.06]
PEIJ exchanges information and opinions with Syril D. Pettit, Executive Director, ILSI Health and Environmental Sciences Institute (HESI)We are continuing to cooperate each other.

[2017.10.28-29]
Inutsuka T and Ide Y. Open science consideration obtained from "MEA Parser" international publication. The 32nd Annual Academic Conference of Japan Society for Research Policy and Innovation Management.

[2017.10.24-25]
NYSCF Conference
PEIJ is working for STEAM education for all in the SDGs using Organ-on-a-Chip.

[2017.08.30]
PEIJ exchanges information and opinions with Syril D. Pettit, Executive Director, ILSI Health and Environmental Sciences Institute (HESI)We are continuing to cooperate each other.

[2017.04.03]
PEIJ provides the "MEA Parser"  (a software to import raw data of MEA equipment and make the binary data of common format, and display wave forms) to HESI Cardiac Safety Committee Myocyte Database Subteam.

[2016.10.27]
PEIJ attended the HESI Myocyte Database Subteam as a member and show our "iPS Integrated Safety Assessment Tool (iSAT)." Under this disucussion, PEIJ is preparing the open-source software "MEA Parser" to import raw data of MEA equipments and make the binary data of common format, and display wave forms.

[2016.10.14]
"Regenerative medicine & Cell therapy industrialization network of Kanagawa (RINK)" is established. PEIJ is one of the Board Member of the RINK.

[2016.09.28]
PEIJ received designation from Minister of Education, Culture, Sports, Science and Technology as the research institute where Grants-in-Aid for Scientific Research-KAKENHI- can be treated.


[2016.08.25]
The life Innovation Center (LIC), where PEIJ is in, opening ceremony is held on August 25, 2016.

[2016.08.15]
PEIJ decides and establishes two research centers for acceleration PEIJ's R&D activities.
- Center for Public Health (CPH) (Director Maya Okamoto, Ph.D.)
- Center for Pharmacological Science (CPS)

[2016.04.01]
Our laboratory moves to the Life Innovation Center (In order to promote industrialization of regenerative medicine and cell therapy, the Government of Kanagawa Prefecture established the “Life Innovation Center” at Tonomachi area in the City of Kawasaki).

[2015.06.01-03]
PEIJ joins Good Cell Culture Practice for iPS workshop, 01-03 June, 2015, Baltimore, USA.

[2014.12.14-15]
PEIJ assists the symposium, Kanagawa Prefecture-NIH/NCATS Symposium -Translational Research Support and Human Resource Development between Japan and United States-, and sets up meetings with Dr. Petra Kaufmann (Director of Clinical Innovation, NCATS) and Dr. Danilo Tagle (Associate Director for Special Initiatives, NCATS).

[2014.9.23]
PEIJ assists the ISN satellite symposium, "Key molecules for neuronal maturation" -Application for validating the maturation of human iPSC-derived neurons-, 23 September, 2014, 13:00~17:20, Tokyo, Japan, and took a role in a general master of this symposium.

[2014.5.12]
PEIJ was established. PEIJ's vision is "make a future together."


3. Achievement

(2017)
Inutsuka T and Ide Y. Open science consideration obtained from "MEA Parser" international publication. The 32nd Annual Academic Conference of Japan Society for Research Policy and Innovation Management.

Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Brain & Development Volume 39, Issue 9, October 2017, Pages 774-782

Okamoto M et al. A COMPARATIVE STUDY OF DAILY MAXIMUM AND PERSONALLY EXPOSED TEMPERATURES DURING HOT SUMMER DAYS OVER THE PAST 7 YEARS IN KOBE, JAPAN --A study to improve “ Quality of Work (QoW) ” in working people. Work, Stress and Health 2017.

Inutsuka T et al. Role of common format data for studying new endpoints in microelectrode arrays (MEA) system. Curr Study Environ Med Sci 10, in press (2017).

Okamoto M et al. Organ-on-a-chip: Role and Perspective. Curr Study Environ Med Sci 10, in press (2017).

(2016)
Kanda Y et al. Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system. Journal of Pharmacological and Toxicological Methods 81 (2016) 196–200.

Pamies D et al. Good Cell Culture Practice for stem cells and stem-cell-derived models. ALTEX Online first published October 5, 2016, version 4.

Ide Y et al. 0040 Cardiac Safety Assessment Methods for Human iPSC-Derived Cardiomyocytes: A Voltage Sensitive Dye Imaging with a High-speed CMOS Sensor and a Non-staining Imaging with Polarizers. The 2016 SPS/CSPT/JSPS Joint Meeting.

A. Alan Moghissi et al. A STUDENT GUIDE TO UNDERSTANDING REGULATORY SCIENCE.

(2014)
A. Alan Moghissi et al. Regulatory science: An emerging new scientific discipline. Rinsho Hyoka; Clin Eval 41 (3) 2014: 597-608

4. About

Boards of Directors:
Shizuo Hoshiba (Representative Director)
Kazuyuki Imamura
Tomoaki Shirao
Norimasa Miyamoto

Adviser:
Dr. Hannu Salmi, Professor, CREATIONS-Project, University of Helsinki, Finland

TEAM PEIJ:
Takashi Inutsuka (Research Managing Director)
Maya Okamoto, Ph.D. (Director, Center for Public Health)
Yoshinori Ide, Ph.D. (Senior Researcher, Center for Pharmacological Science)

PEIJ Laboratory:
3-25-22 Tonomachi, Kawasaki-ku, Kawasaki-City, Kanagawa, Japan 210-0821

Tel: +81-44-272-7187
Fax: +81-50-3730-3851
email: peij*peij.or.jp (please replace * with @)